Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

4.3K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.3K
MicroRNAs01:22

MicroRNAs

24.8K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.8K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

6.1K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
6.1K
Abnormal Proliferation02:23

Abnormal Proliferation

5.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cepharanthine triggers immunogenic cell death in solid tumors by suppressing protein kinase C zeta-mediated poly(ADP-ribose) polymerase 1 expression and synergizes with immunotherapy.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

PTPRN2-mediated silencing of tumor-intrinsic MHC-II promotes immune-excluded tumor microenvironment in colorectal cancer.

Cancer genetics·2026
Same author

CXCL16-driven CD4<sup>+</sup> T cells orchestrate immunosurveillance against MHC-I-deficient hepatocellular tumors.

Journal for immunotherapy of cancer·2026
Same author

NSD2 inhibits the expression of PD-L1 via oxidative phosphorylation to control immune surveillance in hepatocellular carcinoma.

Cell death & disease·2026
Same author

Histone 3 lysine 36 trimethylation by SETD2 shapes an epigenetic landscape in intestinal stem cells to orchestrate lipid metabolism and attenuate cell senescence.

Cell death & disease·2026
Same author

TLR8 agonists remodel the tumor immune microenvironment through PF4-dependent T cell recruitment and ancillary mechanisms.

Cancer immunology, immunotherapy : CII·2026

Related Experiment Video

Updated: Apr 12, 2026

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR
08:30

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR

Published on: May 16, 2012

25.2K

MicroRNAs targeting prostate cancer stem cells.

Yu-Xiang Fang1, Yun-Li Chang1, Wei-Qiang Gao2

  • 1State Key Laboratory of Oncogenes and Related Genes, Renji-MedX Clinical Stem Cell Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

Experimental Biology and Medicine (Maywood, N.J.)
|May 14, 2015
PubMed
Summary

This review explores how microRNAs regulate prostate cancer stem cells, highlighting their role in tumor progression and potential as therapeutic targets for this common male cancer.

Keywords:
EMTPCSCsdrug resistancemetastasismiRNAs

More Related Videos

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.3K
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

7.3K

Related Experiment Videos

Last Updated: Apr 12, 2026

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR
08:30

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR

Published on: May 16, 2012

25.2K
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.3K
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

7.3K

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer is a leading cause of cancer-related deaths globally.
  • Tumor heterogeneity includes cancer stem cells (CSCs) with properties like self-renewal, metastasis, and drug resistance.
  • MicroRNAs (small non-coding RNAs) are implicated in regulating CSCs and tumorigenesis.

Purpose of the Study:

  • To review the functions of microRNAs in regulating the stemness of prostate cancer stem cells.
  • To elucidate the diverse mechanisms by which microRNAs influence prostate CSCs.
  • To propose potential therapeutic applications of microRNAs in prostate cancer treatment.

Main Methods:

  • Literature review of studies on microRNAs and prostate cancer stem cells.
  • Analysis of mechanisms regulating stemness properties (self-renewal, EMT, metastasis, drug resistance).
  • Synthesis of current knowledge on microRNA involvement in prostate CSC biology.

Main Results:

  • MicroRNAs play a critical role in controlling the stemness of prostate cancer stem cells.
  • Specific microRNAs can either promote or inhibit CSC properties through various molecular pathways.
  • Understanding these microRNA-mediated regulations is key to targeting CSCs.

Conclusions:

  • MicroRNAs are significant regulators of prostate cancer stem cell behavior.
  • Targeting microRNAs offers a promising strategy for novel prostate cancer therapies.
  • Further research into microRNA-driven mechanisms can lead to improved treatment outcomes.