Differences between glioblastomas and primary central nervous system lymphomas in 1H-magnetic resonance spectroscopy
Related Experiment Video
Updated: Apr 12, 2026
On-Site Sampling and Extraction of Brain Tumors for Metabolomics and Lipidomics Analysis
Published on: May 31, 2020
Hiroyuki Aburano1, Fumiaki Ueda, Yuichi Yoshie
1Department of Radiology, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan, aburano@arrow.ocn.ne.jp.
Purpose:
The present study aimed to distinguish between glioblastomas and primary central nervous system lymphomas (PCNSLs) using (1)H-magnetic resonance spectroscopy (MRS), especially glutamate (Glu)/creatine (Cr) and Glu/Glu+glutamine (Gln) ratios.
Materials And Methods:
A total of 46 patients (31 cases diagnosed with glioblastoma, 15 with PCNSL) were examined by in vivo single-voxel proton (1)H-MRS with a 3-T MR imaging system. Differences in absolute concentration of Cr, choline/Cr, lipid (1.3 ppm)/Cr, Glu+Gln/Cr, Glu/Cr, and Glu/Glu+Gln ratios among groups were evaluated with Mann-Whitney U tests.
Results:
PCNSLs [3.408 ± 1.194 (standard deviation)] showed significantly higher Glu/Cr ratios as compared to glioblastomas (2.220 ± 0.942; P = 0.003) [Glu/Cr cutoff ratio of 2.509 showed a sensitivity of 88 % (7/8) and a specificity of 92 % (22/24)], while glioblastomas (0.539 ± 0.098) showed significantly lower Glu/Glu+Gln ratios as compared to PCNSLs (0.728 ± 0.147; P < 0.001) [Glu/Glu+Gln cutoff ratio of 0.558 showed a sensitivity of 69 % (18/26) and a specificity of 100 % (13/13)]. And PCNSLs (1.101 ± 0.387) showed significantly higher Cho/Cr ratios as compared to glioblastomas (0.850 ± 0.465; P = 0.026).
Conclusion:
Glu/Cr, Glu/Glu+Gln, and Cho/Cr ratios may be useful in distinguishing between glioblastomas and PCNSLs.
More Related Videos
05:45Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
Published on: July 31, 2017
13:56The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism
Published on: November 19, 2014