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Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass
Published on: August 10, 2017
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Golgi post-translational modifications and associated diseases.
Sven Potelle1, André Klein, François Foulquier
1CNRS-UMR 8576, Structural and Functional Glycobiology unit, FRABIO, University of Lille, 59655, Villeneuve d'Ascq, France.
Journal of Inherited Metabolic Disease
|May 14, 2015
Summary
The Golgi apparatus, crucial for protein modification and targeting, performs diverse post-translational modifications on various proteins. This review highlights key Golgi modifications and associated human diseases.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- The Golgi apparatus is a well-known organelle central to protein secretion and targeting.
- Beyond its canonical roles, the Golgi is significantly involved in diverse post-translational modifications.
- These modifications extend to secreted, transmembrane, and cytoplasmic proteins.
Purpose of the Study:
- To review the primary post-translational modifications occurring within the Golgi apparatus.
- To identify and present diseases associated with Golgi-mediated protein modifications.
Main Methods:
- Literature review of Golgi apparatus functions.
- Analysis of post-translational modification pathways in the Golgi.
- Correlation of identified modifications with disease states.
Main Results:
- The Golgi apparatus executes a wide array of post-translational modifications.
- Specific modifications are linked to distinct cellular functions and protein classes.
- Dysregulation of Golgi modifications contributes to various pathologies.
Conclusions:
- The Golgi apparatus plays a critical, multifaceted role in protein processing.
- Understanding Golgi post-translational modifications is essential for comprehending disease mechanisms.
- Further research into Golgi-associated diseases holds therapeutic potential.
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