Related Experiment Video

Updated: Apr 12, 2026

Advanced Glycation End-Products Sensitize Human Sensory-Like Neuron Cells to Capsaicin-Induced Calcium Influx
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RAGE and its ligands in cancer - culprits, biomarkers, or therapeutic targets?

P Tesarova, M Cabinakova, V Mikulova

    Neoplasma
    |May 14, 2015
    PubMed

    Insights

    The receptor for advanced glycation end products (RAGE) is involved in tissue repair but can promote cancer progression. Targeting RAGE signaling may offer new cancer treatment strategies.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Cell Biology

    Background:

    • The receptor for advanced glycation end products (RAGE) is crucial for tissue homeostasis and inflammation resolution.
    • Pathological RAGE activation can lead to reduced apoptosis, increased autophagy, and cell necrosis, potentially driving cancer development.

    Purpose of the Study:

    • To investigate the role of RAGE in malignant transformation, cancer progression, and metastasis.
    • To explore the potential of soluble RAGE as a cancer biomarker.
    • To evaluate RAGE-signaling interference as an anticancer therapeutic strategy.

    Main Methods:

    • Review of literature on RAGE pathways in cancer.
    • Analysis of RAGE expression and soluble RAGE levels in various cancer types.
    • Examination of RAGE-mediated cellular mechanisms (apoptosis, autophagy, necrosis).

    Main Results:

    • RAGE activation is implicated in diminished apoptosis and enhanced autophagy/necrosis, contributing to cancer progression.
    • RAGE expression and soluble RAGE levels are observed in colon, pancreatic, and breast cancers.
    • Soluble RAGE can neutralize RAGE ligands, potentially counteracting RAGE-mediated effects.

    Conclusions:

    • RAGE plays a dual role in tissue repair and cancer development.
    • RAGE and soluble RAGE show potential as cancer biomarkers.
    • Targeting RAGE signaling represents a promising therapeutic avenue for anticancer drug development.
    Keywords:
    HMGB1RAGES100 proteins.cancer

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