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Pazopanib and pancreatic toxicity: a case report
Marco Russano1, Bruno Vincenzi2, Olga Venditti3
1Department of Medical Oncology, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 200, 00128, Rome, Italy. m.russano@unicampus.it.
BMC Research Notes
|May 14, 2015
Summary
Pazopanib, a tyrosine-kinase inhibitor for advanced renal cell carcinoma, can cause asymptomatic increases in pancreatic enzymes. Careful monitoring is recommended during treatment, as toxicity may not be dose-dependent.
Area of Science:
- Oncology
- Pharmacology
Background:
- Pazopanib is an oral multitargeted tyrosine-kinase inhibitor used for advanced renal cell carcinoma.
- Other tyrosine-kinase inhibitors are known to cause asymptomatic elevations in serum amylase and lipase.
- Limited data exist regarding pazopanib's effect on pancreatic enzymes.
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