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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Papillary Dermis01:11

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Abnormal Proliferation02:23

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Reticular Dermis01:15

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Related Experiment Video

Updated: Apr 12, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
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Regressing Eruptive Disseminated Spitz Nevi.

Bevin Bhoyrul1, Diana Y L Tang1, Edward E Carling2

  • 1Department of Dermatology, James Cook University Hospital, Middlesbrough, UK.

Pediatric Dermatology
|May 14, 2015
PubMed
Summary

Eruptive disseminated Spitz nevi (EDSN) is rare and cosmetically concerning. Long-term observation showed significant regression in a pediatric case, suggesting it

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Area of Science:

  • Dermatology
  • Pediatric Dermatology
  • Pathology

Background:

  • Eruptive disseminated Spitz nevi (EDSN) is a rare variant of Spitz nevi.
  • It presents significant cosmetic concerns and has a poorly understood natural history.
  • Currently, there is no established satisfactory treatment for EDSN.

Observation:

  • A case report of a 4-year-old boy with over 100 Spitz nevi is presented.
  • The nevi exhibited an eruptive and disseminated pattern.
  • The patient was observed over an 8-year period following the onset of the lesions.

Findings:

  • The Spitz nevi in the reported case demonstrated significant regression over the 8-year observation period.
  • No instances of supervening malignancy were reported in association with the EDSN.
  • This case supports the potential for spontaneous resolution of EDSN.

Implications:

  • Long-term observation may be a safe and acceptable management strategy for EDSN.
  • This approach avoids the need for potentially ineffective or invasive treatments.
  • Further studies are warranted to confirm the natural history and optimal management of EDSN.