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Developing a Rat Model for Bipolar Disorder
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Screening for bipolar disorder during pregnancy.

Lindsay Merrill1, Leena Mittal, Jennifer Nicoloro

  • 1Department of Psychiatry, Newton Wellesley Hospital, Newton, MA, USA.

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Screening pregnant individuals for bipolar disorder is crucial. This pilot study found that many cases would be missed if only depression is screened for, highlighting the need for simultaneous screening.

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Area of Science:

  • Obstetrics and Gynecology
  • Psychiatry
  • Perinatal Mental Health

Background:

  • Bipolar disorder presents significant risks during pregnancy.
  • Current screening practices may overlook bipolar disorder in pregnant individuals.
  • Misclassification of bipolar depression as unipolar depression is a concern.

Purpose of the Study:

  • To determine the proportion of pregnant women screening positive for bipolar disorder, with or without concurrent depression.
  • To assess the overlap between depression and bipolar disorder screening in prenatal care.
  • To advocate for integrated screening protocols for perinatal mood disorders.

Main Methods:

  • Pilot study utilizing chart abstraction of screening tool scores.
  • Edinburgh Postnatal Depression Scale (EPDS) and Mood Disorder Questionnaire (MDQ) were administered at initial prenatal visits.
  • Analysis of screening results from 342 pregnant participants.

Main Results:

  • Positive screening rates were 16.4% for depression (EPDS) and 5.1% for bipolar disorder (MDQ).
  • Of those with positive depression screens, 21.4% also screened positive for bipolar disorder.
  • Approximately one-third of bipolar disorder cases would be missed if only depression was screened.

Conclusions:

  • The prevalence of positive bipolar disorder screens in obstetric populations warrants routine screening.
  • Simultaneous screening for depression and bipolar disorder is recommended to avoid misdiagnosis and missed cases.
  • Integrated screening can improve perinatal mental health care for pregnant individuals.