Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-Time Detection of Colorectal Cancer Using Topical Application of a pH-Activatable Fluorophore.

Molecular diagnosis & therapy·2026
Same author

Longitudinal Study of Familism, Inflammation, and Metabolic Syndrome in Black Adolescents From Lower-Income Households.

Biopsychosocial science and medicine·2026
Same author

Relationship between remission rate of type 2 diabetes and skeletal muscle after laparoscopic sleeve gastrectomy.

Biomedical reports·2026
Same author

Near-infrared fluorescence imaging-guided targeted drug delivery in gastric tumors: From molecular design to clinical translation.

Advanced drug delivery reviews·2026
Same author

A tumor-targeted heptamethine cyanine dye suppresses triple-negative breast cancer by induction of lethal autophagy.

Theranostics·2026
Same author

Comparison of D2 and Non-D2 Lymphadenectomy in Older Patients (≥75 years) Undergoing Minimally Invasive Distal Gastrectomy for Gastric Cancer: A Multicenter Retrospective Propensity Score-matched Analysis.

Anticancer research·2026
Same journal

ASO Author Reflections: Does the Axilla Still Matter? Rethinking Nodal Staging in the Era of CDK4/6 Inhibition.

Annals of surgical oncology·2026
Same journal

Omission of Axillary Surgery in Patients with Invasive Lobular Carcinoma of the Breast: Rates of Nodal Involvement in Clinically Node Negative Patients and Impact on Recurrence in a Single Institution Analysis.

Annals of surgical oncology·2026
Same journal

Is Mastectomy Necessary in Patients with Occult Breast Cancer and Advanced (N2/N3) Nodal Disease?

Annals of surgical oncology·2026
Same journal

Expanding Eligibility for Targeted Axillary Dissection.

Annals of surgical oncology·2026
Same journal

ASO Author Reflections: Reconsidering Surgical Indications for Clinical T4 Non-Small Cell Lung Cancer in the TNM 9th Edition Era.

Annals of surgical oncology·2026
Same journal

Potential Impact of Sentinel Lymph Node Biopsy Omission on Adjuvant Treatment Decisions in Low-Risk Breast Cancer: A Regional Multicenter 775 Patient Review of Current Practice in the United Kingdom.

Annals of surgical oncology·2026
See all related articles

Related Experiment Video

Updated: Apr 12, 2026

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

14.0K

Sentinel Lymph Node Mapping of Liver.

Hideyuki Wada1,2, Hoon Hyun1, Christina Vargas1,3

  • 1Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

Annals of Surgical Oncology
|May 14, 2015
PubMed
Summary
This summary is machine-generated.

This study demonstrates that near-infrared (NIR) imaging can identify sentinel lymph nodes (SLNs) and all regional lymph nodes (RLNs) in the liver, potentially improving surgical management for liver cancer.

More Related Videos

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
07:51

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

Published on: June 1, 2019

22.0K
Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques
11:06

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques

Published on: May 2, 2017

51.8K

Related Experiment Videos

Last Updated: Apr 12, 2026

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

14.0K
The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
07:51

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

Published on: June 1, 2019

22.0K
Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques
11:06

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques

Published on: May 2, 2017

51.8K

Area of Science:

  • Surgical oncology
  • Medical imaging
  • Gastroenterology

Background:

  • The existence and mapping of hepatic sentinel lymph nodes (SLNs) remain uninvestigated.
  • Accurate nodal staging is crucial for managing intrahepatic malignancies like cholangiocarcinoma.
  • SLN identification could enable less invasive surgical approaches for liver cancers.

Purpose of the Study:

  • To determine if hepatic SLNs exist.
  • To evaluate near-infrared (NIR) fluorescent dyes for simultaneous SLN and regional lymph node (RLN) mapping in the liver.
  • To assess the potential of NIR imaging for guiding surgical resection of liver malignancies.

Main Methods:

  • The study utilized 25 Yorkshire pigs to investigate hepatic SLN and RLN mapping.
  • Four NIR fluorophores were compared: methylene blue, indocyanine green (ICG), ESNF14, and ZW800-3C.
  • NIR imaging was employed to assess dye distribution, retention, and leakage for lymph node identification.

Main Results:

  • ESNF14 demonstrated optimal performance for SLN identification with high signal-to-background and prolonged retention.
  • ZW800-3C, when administered intravenously, effectively mapped all liver RLNs over a 4-6 hour period.
  • Simultaneous dual-channel imaging using ESNF14 and ZW800-3C allowed precise, image-guided resection of identified SLNs and RLNs.

Conclusions:

  • Near-infrared (NIR) imaging technology facilitates real-time, intraoperative identification of SLNs and RLNs within the liver.
  • These findings in swine suggest potential for novel surgical strategies in treating intrahepatic malignancies.
  • Further validation in human patients is warranted to confirm the clinical applicability of this NIR imaging approach.