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Updated: Apr 12, 2026

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
Published on: June 16, 2023
Targeting L-type amino acid transporter 1 for anticancer therapy: clinical impact from diagnostics to therapeutics
Su-Eon Jin1, Hyo-Eon Jin2, Soon-Sun Hong3
1a 1 Yonsei University, College of Pharmacy , Incheon, 406-840, Republic of Korea.
Introduction:
L-type amino acid transporter 1 (LAT1) is one of the amino acid transporters. It is overexpressed in various types of cancer cells, while it is produced restrictedly in normal tissues.
Areas Covered:
We discuss its characteristics in cancer cells compared with normal cells. We also mention the current applications to target LAT1 for anticancer therapy focusing on prognostic biomarkers, radio-labeled tumor imaging reagents, amino acid-stapled prodrugs, LAT1-mediated enhanced transport of anticancer drugs and LAT1 inhibitors.
Expert Opinion:
LAT1 can be a versatile target to promisingly develop transporter-based drugs with enhanced drug delivery potential for anticancer therapy.
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