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Updated: Apr 12, 2026

Identification of Metal Oxide Nanoparticles in Histological Samples by Enhanced Darkfield Microscopy and Hyperspectral Mapping
Published on: December 8, 2015
Scanning metallic nanosphere microscopy for vectorial profiling of optical focal spots
Abstract:
Recent years have witnessed fast progress in the development of spatially variant states of polarization under high numerical aperture focusing, and intensive exploration of their applications. We report a vectorial, broadband, high contrast and subwavelength resolution method for focal spot profiling. In this experiment, a 100 nm diameter gold nanosphere on a silica aerogel substrate is raster scanned across the focal spots, and the orthogonal polarization components can be obtained simultaneously by measuring the scattering far field in a confocal manner. The metallic-nanosphere-on-aerogel structure ensures negligible distortion to the focal spots, low crosstalk between orthogonal polarization components (1/39 in experiment), and a low level background noise (1/80 of peak intensity in experiment), while high contrast imaging is not limited by the resonance bandwidth.
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