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Related Experiment Videos

Ankylosing spondylitis--experience with a self administered questionnaire: an analytical study.

V S Ringsdal1, J J Andreasen

  • 1Department of Rheumatology, Copenhagen County Hospital, Glostrup, Denmark.

Annals of the Rheumatic Diseases
|November 1, 1989
PubMed
Summary

Diagnosis of ankylosing spondylitis (AS) is significantly delayed, especially in women. This study highlights the need for earlier AS detection and management to improve patient outcomes.

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Area of Science:

  • Rheumatology
  • Epidemiology
  • Patient-Reported Outcomes

Background:

  • Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton.
  • Delayed diagnosis is a significant challenge in managing AS, impacting patient prognosis and quality of life.

Purpose of the Study:

  • To investigate diagnostic delays and disease characteristics in a cohort of Danish patients with ankylosing spondylitis.
  • To identify potential differences in disease presentation and progression between sexes and onset types.

Main Methods:

  • A questionnaire was administered to 179 consecutive patients with AS from the Danish Ankylosing Spondylitis Society (DASS).
  • Data collected included age at onset, diagnostic delay, disease progression (stiffness), and extra-articular manifestations.

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  • Statistical analysis compared outcomes based on sex and age at disease onset (juvenile vs. adult).

    • Main Results:

    • The average diagnostic delay for AS was 12.6 years for women and 9.5 years for men.
    • Juvenile onset AS showed a higher incidence of initial peripheral joint involvement.
    • Extra-articular manifestations, including iritis and conjunctivitis, were more common in women.
    • Significant disease progression, particularly stiffness, was observed in both sexes over time.

    Conclusions:

    • This study confirms substantial diagnostic delays in ankylosing spondylitis, particularly for women, underscoring the need for improved early detection strategies.
    • Questionnaires offer a cost-effective method for collecting comprehensive patient data and updating disease information.
    • Understanding sex-based differences in AS presentation and progression is crucial for tailored patient care.