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    We developed methods to reduce fixed-pattern noise in swept source optical coherence tomography (SS-OCT) by aligning interferograms. The intensity-based method effectively minimized noise, improving phase stability for clearer OCT imaging.

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    Area of Science:

    • Biomedical Optics
    • Optical Imaging
    • Medical Physics

    Background:

    • Swept source optical coherence tomography (SS-OCT) systems can suffer from fixed-pattern noise due to trigger jitter.
    • This noise degrades image quality and reduces phase stability, impacting diagnostic accuracy.
    • Accurate interferogram alignment is crucial for mitigating these artifacts.

    Purpose of the Study:

    • To propose and evaluate novel methods for aligning interferograms affected by trigger jitter in SS-OCT.
    • To reduce residual fixed-pattern noise and enhance phase stability in SS-OCT systems.
    • To compare the efficacy of intensity-based versus phase-based wavenumber alignment techniques.

    Main Methods:

    • Developed two methods for interferogram alignment based on fixed-pattern noise locations.
    • Method 1: Introduced a wavenumber shift (k-shift) and optimized it to minimize noise amplitude.
    • Method 2: Calculated relative k-shift using phase information at noise locations.

    Main Results:

    • Both methods successfully reduced fixed-pattern noise and improved phase stability.
    • The intensity-based k-shift optimization method demonstrated superior performance compared to the phase-based method.
    • Applied correction routines to human retina SS-OCT and Doppler OCT imaging, yielding artifact-free images.

    Conclusions:

    • Wavenumber alignment is an effective strategy for correcting SS-OCT interferograms affected by trigger jitter.
    • The intensity-based method offers a robust solution for reducing fixed-pattern noise and enhancing phase stability.
    • These techniques significantly improve the quality and reliability of SS-OCT imaging for clinical applications.