Phase retrieval method for in-line phase contrast x-ray imaging and denoising by regularization
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Updated: Apr 12, 2026

3D Imaging of Soft-Tissue Samples using an X-ray Specific Staining Method and Nanoscopic Computed Tomography
Published on: October 24, 2019
Abstract:
Phase contrast X-ray imaging is increasingly popular in the past decade. In order to acquire phase contrast X-ray images, different types of imaging mechanisms have been proposed. Among them, in-line phase contrast X-ray imaging shows the highest potential because of its simplicity. In the study of in-line phase contrast imaging, based on different physical assumptions, many non-iterative phase retrieval methods, such as Bronnikov method, modified Bronnikov method, phase-attenuation duality (PAD) method, single-material method, and two-material method have been proposed. The main step of the non-iterative methods is a filtering process, thus different methods involve different filter design. In this paper we showed that every filter applied in the methods listed above is indeed the minimizer of a L(2)-norm regularization problem. In addition, two methods were proposed to overcome the over smoothing problem owing to the nature of L(2)-norm regularization.
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Phase Contrast and Differential Interference Contrast Microscopy
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
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