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Large animal model of left ventricular aneurysm
L J Markovitz1, E B Savage, M B Ratcliffe
1Department of Surgery, University of Pennsylvania, Philadelphia 19104.
The Annals of Thoracic Surgery
|December 1, 1989
Summary
Sheep models consistently develop left ventricular aneurysms after coronary artery ligation, aiding studies on myocardial infarction and ventricular mechanics. This ovine model offers advantages for metabolic and mechanical research.
Area of Science:
- Cardiovascular Science
- Animal Models
- Myocardial Infarction Research
Background:
- Acute myocardial infarction (AMI) can lead to left ventricular aneurysm (LVA).
- Ovine models are increasingly used to study cardiac pathophysiology.
- Understanding LVA formation is crucial for developing effective treatments.
Purpose of the Study:
- To characterize the development of left ventricular aneurysms in sheep following coronary artery ligation.
- To evaluate the ovine coronary anatomy and its suitability for infarction models.
- To highlight the advantages of the ovine model for studying AMI and LVA.
Main Methods:
- Ligation of distal coronary arteries in 28 Dorsett sheep to induce myocardial infarction.
- Serial left ventriculography to assess infarct segment changes and aneurysm formation over 60 days.
- Anatomical study of coronary vasculature in 22 excised sheep hearts.
Main Results:
- Coronary artery ligation consistently produced transmural infarcts (22.9% of left ventricular mass).
- Infarct segments expanded, decreased in wall thickness, and progressed to aneurysmal dilatation within 4 hours and over 60 days.
- Adjacent noninfarcted myocardium contributed to aneurysm formation.
- Ovine coronary anatomy is constant, with the left coronary artery supplying the left ventricle and septum.
Conclusions:
- The ovine model reliably replicates myocardial infarction and subsequent left ventricular aneurysm formation.
- The distinct coronary circulation and limited collateral supply in sheep are advantageous for infarction studies.
- This model is well-suited for metabolic and mechanical investigations of AMI and LVA.