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Ocular juvenile xanthogranuloma.

Liangliang Niu1, Chaoran Zhang, Fanrong Meng

  • 1*MD †MD, PhD Departments of Ophthalmology (LN, CZ, FM, YW, JX) and Pathology (RC, YB), Eye and ENT Hospital of Fudan University, Shanghai, China.

Optometry and Vision Science : Official Publication of the American Academy of Optometry
|May 14, 2015
PubMed
Summary
This summary is machine-generated.

Juvenile xanthogranuloma (JXG) of the eye can affect the corneoscleral limbus, conjunctiva, or iris. Surgical excision is effective for ocular surface JXG, while iris JXG may resolve spontaneously.

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Area of Science:

  • Ophthalmology
  • Dermatology
  • Pediatrics

Background:

  • Juvenile xanthogranuloma (JXG) is a rare, benign, non-Langerhans cell histiocytosis.
  • Ocular involvement in JXG can present with diverse clinical manifestations.

Observation:

  • Three pediatric cases of ocular JXG are presented, involving the corneoscleral limbus, conjunctiva, and iris.
  • Clinical presentations included yellowish masses, corneal involvement, and skin lesions.
  • Ultrasound biomicroscopy revealed poorly demarcated masses in two cases.

Findings:

  • Histopathologic examination confirmed JXG with Touton giant cells and CD68 positivity.
  • Ocular surface JXG (limbus and conjunctiva) treated with excision showed no recurrence.
  • Iris JXG spontaneously regressed without intervention.

Implications:

  • Early surgical excision is recommended for ocular surface JXG, particularly with corneal involvement.
  • Spontaneous regression is possible for intraocular JXG.
  • Accurate diagnosis through histopathology is crucial for appropriate management.