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Molecular cloning of the Rauscher murine leukemia virus. Disease spectrum and integration pattern
M J van der Feltz1, M E Kranendonk-Odijk, E H Rhijnsburger
1Department of Pathology, Faculty of Medicine, Erasmus University Rotterdam, The Netherlands.
Archives of Virology
|January 1, 1989
Abstract:
After transfection of NIH 3T3 cells with DNA from molecularly cloned Rauscher MuLV, virus was isolated which showed a disease spectrum comparable to that of R-MuLV cloned biologically by endpoint dilution. In both cases sites of proviral integration vary from 2-5 per leukemic tissue and occur apparently at random.