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Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Related Experiment Video

Updated: Apr 12, 2026

$Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus$

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

Osteoarticular transplantation: recognizing expected postsurgical appearances and complications.

Jennifer L Favinger¹, Alice S Ha, Michael E Brage

¹From the Departments of Radiology (J.L.F., A.S.H., F.S.C.) and Orthopedic Surgery (M.E.B.), University of Washington Medical Center, 4245 Roosevelt Way NE, Box 354755, Seattle, WA 98105.

Radiographics : a Review Publication of the Radiological Society of North America, Inc

|May 14, 2015

Summary

Allografts, or biologic tissue grafts from donors, offer limb salvage for young patients with significant bone or soft tissue loss. While effective, potential complications like nonunion and infection require careful monitoring.

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$Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus$

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Area of Science:

Orthopedic Surgery
Biomaterials Science
Musculoskeletal Oncology

Background:

Prosthetic joint implants have limitations in longevity, especially for young patients with extensive bone or soft tissue loss due to tumors or trauma.
Biologic tissue grafts, including allografts (cadaveric) and osteochondral autografts (patient's own tissue), are increasingly used in orthopedic surgery.
These grafts range from small plugs to entire joint replacements, offering limb preservation and avoiding amputation in cases of large-volume bone loss.

Purpose of the Study:

To review the indications, surgical procedures, and imaging findings associated with allograft and autograft transplantation in orthopedics.
To highlight the advantages and disadvantages of using allografts compared to autografts.
To describe potential complications and their imaging features following biologic tissue implantation.

Main Methods:

Discussion of surgical techniques for local osteochondral plug implantation and whole joint allograft replacement.
Review of pre- and postoperative imaging appearances of transplanted tissues.
Analysis of imaging characteristics indicative of common allograft complications.

Main Results:

Allografts preserve limb function in patients with large-volume bone loss, presenting an alternative to amputation.
Advantages include tissue similarity to native structures and reduced donor site morbidity.
Disadvantages involve slower graft incorporation and potential complications such as nonunion, collapse, infection, and secondary osteoarthritis.

Conclusions:

Biologic tissue grafts, particularly allografts, are valuable options for young patients with substantial bone and soft tissue defects.
Understanding normal and abnormal imaging is crucial for managing patients post-transplantation.
Careful patient selection and monitoring are essential to mitigate risks and optimize outcomes.