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Updated: Apr 12, 2026

Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers
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Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers

Published on: July 15, 2019

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Salivary gland development and disease

Aaron Mattingly1, Jennifer K Finley1, Sarah M Knox1

  • 1Department of Cell & Tissue Biology, University of California San Francisco, San Francisco, CA 94143, USA.

Wiley Interdisciplinary Reviews. Developmental Biology
|May 14, 2015
PubMed

Mammalian salivary glands synthesize and secrete saliva via a vast interconnected network of epithelial tubes attached to secretory end units. The extensive morphogenesis required to establish this organ is dependent on interactions between multiple cell types (epithelial, mesenchymal, endothelial, and neuronal) and the engagement of a wide range of signaling pathways. Here we describe critical regulators of salivary gland development and discuss how mutations in these impact human organogenesis. In particular, we explore the genetic contribution of growth factor pathways, nerve-derived factors and extracellular matrix molecules to salivary gland formation in mice and humans.

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