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Updated: Apr 12, 2026

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein
Published on: July 29, 2022
Interferon-alpha caused reversible parkinsonism
Chieh-Sheng Lu1, Wei-Yau Kao, Jiann-Chyun Lin
1*Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan; †Division of Hematology/Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center; ‡Division of Hematology/Oncology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei; §Division of Hematology/Oncology, Department of Internal Medicine, Buddhist Taipei Tzu Chi Hospital, Taipei; and ∥Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Abstract:
Interferon has been used to treat chronic viral hepatitis and several malignancies. However, it may cause various neuropsychiatric adverse effects including parkinsonism. We report a rare case of interferon alpha-2a therapy-related parkinsonism in a 67-year-old man with metastatic papillary renal cell carcinoma and our experience of using Tc-99m-TRODAT-1 single photon emission computed tomography (SPECT) as a tool for evaluation of parkinsonism. Physicians should be alert to the possibility of interferon alpha-2a-related parkinsonism.
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