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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Lineage Commitment01:21

Lineage Commitment

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Commitment is the  process whereby stem cells:
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Overview of Hematopoiesis01:20

Overview of Hematopoiesis

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
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Production of Formed Elements01:34

Production of Formed Elements

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Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
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Updated: Apr 12, 2026

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
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Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

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Systems mapping for hematopoietic progenitor cell heterogeneity.

Linghua Zhou1, Yong Shen1, Libo Jiang1

  • 1Center for Computational Biology, Beijing Forestry University, Beijing, People's Republic of China.

Plos One
|May 14, 2015
PubMed
Summary
This summary is machine-generated.

We developed a new statistical model to map genetic factors influencing cell heterogeneity. This approach identifies quantitative trait loci (QTLs) and methylated QTLs, offering insights into hematopoietic progenitor cell diversity.

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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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Simultaneous Assessment of Kinship, Division Number, and Phenotype via Flow Cytometry for Hematopoietic Stem and Progenitor Cells
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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

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Area of Science:

  • Genetics
  • Systems Biology
  • Developmental Biology

Background:

  • Cellular phenotypes can vary even with identical genotypes and environments, a phenomenon termed population heterogeneity.
  • Heterogeneity in hematopoietic progenitor cells significantly impacts their differentiation potential and lineage commitment.
  • The underlying genetic mechanisms driving population heterogeneity are not yet fully understood.

Purpose of the Study:

  • To present a novel statistical model for mapping quantitative trait loci (QTLs) associated with hematopoietic cell heterogeneity.
  • To integrate systems biology approaches, specifically differential equations, into QTL mapping for analyzing genetic influences on cell heterogeneity.
  • To investigate both genetic (QTLs) and non-genetic (methylated QTLs) factors contributing to cellular diversity.

Main Methods:

  • Development of a statistical model for quantitative trait locus (QTL) mapping tailored for cell heterogeneity.
  • Integration of a system of differential equations within the systems mapping framework to model genetic influences.
  • Utilization of a simulation approach based on cell heterogeneity dynamics to validate the model's statistical properties.

Main Results:

  • The proposed model successfully maps quantitative trait loci (QTLs) affecting hematopoietic cell heterogeneity.
  • The model identifies methylated quantitative trait loci (mQTLs), highlighting the role of epigenetic modifications in non-genetic individual differences.
  • The systems mapping strategy allows for testing hypotheses about the interaction between genetic factors and cell heterogeneity dynamics.

Conclusions:

  • The developed statistical model provides a powerful tool for dissecting the genetic architecture of population heterogeneity.
  • The identification of both QTLs and methylated QTLs underscores the complex interplay of genetic and epigenetic factors in cellular diversity.
  • This approach has significant implications for understanding the molecular, genetic, and epigenetic underpinnings of hematopoietic progenitor cell heterogeneity.