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Related Experiment Video

Updated: Apr 12, 2026

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
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Thyroid fine-needle biopsy: aspiration versus capillary.

C M Buzdugă, Corina Găleşanu, Carmen Vulpoi

    Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
    |May 15, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Thyroid fine-needle biopsy (FNB) techniques, aspiration and nonaspiration, showed no significant differences in smear quality. Both methods are suitable for screening thyroid nodular lesions.

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    Area of Science:

    • Endocrinology
    • Pathology
    • Cytopathology

    Background:

    • Thyroid nodules are common, requiring accurate diagnostic methods.
    • Fine-needle biopsy (FNB) is the primary diagnostic tool for thyroid nodules.
    • Previous studies suggested potential differences between aspiration and nonaspiration FNB.

    Purpose of the Study:

    • To compare the quality of thyroid smears obtained by aspiration versus nonaspiration FNB.
    • To determine if significant differences exist in key smear characteristics between the two techniques.

    Main Methods:

    • A comparative study involving 309 patients with thyroid nodules.
    • Fine-needle aspiration biopsy (FNA) and fine-needle nonaspiration biopsy (FNNB) were performed.
    • Smear quality was assessed by a single pathologist using the Mair scoring system, evaluating blood contamination, cellularity, degeneration, trauma, and architecture.

    Main Results:

    • No statistically significant differences were observed in smear quality between aspiration and nonaspiration FNB.
    • Key parameters evaluated included blood contamination, cellular material quantity, cellular degeneration, cellular trauma, and architectural preservation.
    • Both techniques yielded comparable results in terms of diagnostic sample adequacy.

    Conclusions:

    • Both aspiration and nonaspiration fine-needle biopsy techniques produce comparable smear quality for thyroid nodules.
    • The sensitivity and specificity of both methods support their use as standard screening tools for thyroid nodular lesions.
    • Clinicians can confidently utilize either FNB technique for initial assessment of thyroid nodules.