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Updated: Apr 12, 2026

Author Spotlight: Advancing VRL Diagnosis Using Cell-Free DNA Extraction from Vitreous Humor
Published on: January 12, 2024
Primary vitreoretinal lymphoma
Kaustubh Mulay, Ritesh Narula, Santosh G Honavar1
1Department of Ocular Oncology, Centre for Sight Superspeciality Eye Hospital, Hyderabad, India.
Abstract:
Primary vitreoretinal lymphoma (PVRL) is an uncommon, but potentially fatal intraocular malignancy, which may occur with or without primary central nervous system lymphoma (PCNSL). Considered to be a subset of PCNSL, it is mostly of diffuse large B-cell type. The diagnosis of PVRL poses a challenge not only to the clinician, but also to the pathologist. Despite aggressive treatment with chemotherapy and/or radiotherapy, relapses or CNS involvement are common.
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