Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

5.5K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.5K
Clinical Trials01:16

Clinical Trials

11.2K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
11.2K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

565
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
565
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

1.6K
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
1.6K
Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

1.9K
Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
1.9K
Preclinical Development: Overview01:28

Preclinical Development: Overview

6.5K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
6.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Football-Specific On-Pitch Concussion Assessment Protocol-International Consensus Recommendations.

JAMA neurology·2026
Same author

Mucoactive agents in bronchiectasis: a systematic review and meta-analysis.

European respiratory review : an official journal of the European Respiratory Society·2026
Same author

Low concentration atropine eye drops and progression of myopia in children: multicentre placebo controlled, double masked, randomised trial in the UK (CHAMP-UK).

BMJ (Clinical research ed.)·2026
Same author

Carbocisteine or Hypertonic Saline for Acute Respiratory Failure.

The New England journal of medicine·2026
Same author

Randomised controlled feasibility trial of an intervention to increase activity and reduce sedentary behaviour in people with severe mental illness: Walking fOR Health (WORtH) study.

BMJ open·2026
Same author

Concordance between automated/semi-automated measurement and manual assessment of mammographic breast density in individuals undergoing breast cancer screening: A systematic review.

Journal of medical screening·2026

Related Experiment Video

Updated: Apr 12, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

7.3K

Core outcome sets and trial registries.

Mike Clarke1, Paula Williamson2

  • 1Northern Ireland Network for Trials Methodology Research, Centre for Public Health, Institute of Clinical Sciences, Block B, Queens University Belfast, Royal Hospitals, Grosvenor Road, Belfast, BT12 6BJ, UK. m.clarke@qub.ac.uk.

Trials
|May 15, 2015
PubMed
Summary

Registering clinical trials helps reduce research waste. Using core outcome sets and noting them in registries ensures trials are more useful for systematic reviews and improving health outcomes.

More Related Videos

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.4K
Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

15.5K

Related Experiment Videos

Last Updated: Apr 12, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

7.3K
In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.4K
Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

15.5K

Area of Science:

  • Clinical trial registration
  • Research methodology
  • Health outcomes research

Background:

  • Trial registration aids awareness of ongoing studies, reducing research waste.
  • Inconsistent outcome measurement and selective reporting contribute to research waste.
  • Core outcome sets standardize essential outcomes for research in specific health areas.

Purpose of the Study:

  • To propose integrating core outcome set usage into trial registry entries.
  • To enhance the utility of clinical trials and minimize research waste.
  • To improve the transparency and comparability of trial data for systematic reviews.

Main Methods:

  • Suggesting modifications to trial registry entry fields, specifically the outcomes section.
  • Encouraging researchers to declare the use of a core outcome set.
  • Facilitating links to established core outcome sets within registry platforms.

Main Results:

  • Increased awareness of ongoing and unpublished studies.
  • Potential reduction in research waste due to inconsistent or selectively reported outcomes.
  • Improved data for systematic reviews and evidence synthesis.

Conclusions:

  • Trial registries can play a crucial role in promoting the use of core outcome sets.
  • This integration will enhance trial transparency, reduce waste, and improve the quality of evidence for healthcare decision-making.
  • Registries can facilitate the standardization of outcome measurement, leading to more comparable and useful research.