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Quantitative microscopy of mole rat eosinophil granule morphology
Dina Amihai1, Isaac Meilijson2, Joseph Terkel3
1Sackler Faculty of Medicine, Department of Pathology, Tel Aviv University, Tel Aviv, 6997801, Israel.
Cell and Tissue Research
|May 15, 2015
Summary
Mole rat eosinophil granules change shape from sphere-like to ellipsoidal, conserving volume and membrane. This morphological shift may be an adaptation to their solitary lifestyle, impacting inflammatory responses.
Area of Science:
- Cell Biology
- Morphology
- Eosinophil Granules
Background:
- Eosinophils store mediators in unique crystalloid granules.
- Granule morphology is crucial for cellular function and mediator release.
Purpose of the Study:
- To investigate the morphological maturation of mole rat eosinophil granules.
- To compare granule morphology between bone marrow and peritoneal eosinophils.
- To understand the functional implications of granule shape changes.
Main Methods:
- Quantitative microscopy of mole rat bone marrow and peritoneal eosinophils.
- Morphometric analysis of granule size, shape, and volume distribution.
- Mathematical modeling to infer intragranular processes.
Main Results:
- Bone marrow eosinophils have sphere-like granules with a multimodal volume distribution.
- Peritoneal eosinophils have cigar-shaped granules with variable crystalloid cores.
- A conserved granule volume quantum suggests sphere-to-ellipsoid transformation.
Conclusions:
- Mole rat eosinophil granules transform from sphere-like to ellipsoidal shapes, conserving volume and membrane.
- This shape change is likely an adaptive response to their solitary life.
- Understanding this process offers insights into allergic inflammation and host defense.
