Related Experiment Video

Updated: Apr 12, 2026

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

985

Hyperglycemia and Mortality Risk in Patients with Primary Intracerebral Hemorrhage: A Meta-Analysis

Xiaoming Guo1, Helin Li2, Zhiwen Zhang3

  • 1Neurosurgery Department, The First Affiliated Hospital of General Hospital of PLA, Beijing, 100048, China. guoqzgz@sina.cn.

Molecular Neurobiology
|May 15, 2015
PubMed

Insights

Hyperglycemia, or high blood sugar, significantly increases mortality risk in patients with primary intracerebral hemorrhage. This elevated blood sugar impacts both short-term and long-term survival rates.

Area of Science:

  • Neurology
  • Endocrinology
  • Critical Care Medicine

Background:

  • Hyperglycemia is a common complication in patients with primary intracerebral hemorrhage (ICH).
  • The association between hyperglycemia and patient outcomes in ICH requires further clarification.

Purpose of the Study:

  • To systematically review and meta-analyze existing literature.
  • To investigate the relationship between hyperglycemia and mortality risk in primary ICH patients.

Main Methods:

  • Searched PubMed and Embase databases for relevant studies.
  • Included 17 studies comprising 6527 primary ICH patients.
  • Estimated pooled relative risk (RR) with 95% confidence intervals (CI) for mortality.

Main Results:

  • Hyperglycemia significantly increased mortality risk in primary ICH patients (RR = 2.36, 95% CI 1.79-3.12).
  • Elevated glucose levels were linked to increased short-term (RR = 3.97, 95% CI 2.13-7.43) and long-term mortality (RR = 1.53, 95% CI 1.14-2.05).
  • Each 1-mmol/L increase in glucose raised mortality risk (RR = 1.14, 95% CI 1.06-1.22).

Conclusions:

  • Hyperglycemia is a significant risk factor for mortality in primary intracerebral hemorrhage.
  • Effective management of hyperglycemia may improve survival outcomes in these patients.

Keywords:
Hemorrhagic strokeHyperglycemiaMortality

More Related Videos

Improving IV Insulin Administration in a Community Hospital12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.5K
Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation09:01

Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation

Published on: October 15, 2021

8.9K

Related Concept Videos

Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
1.3K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.9K
Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
4.6K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.8K
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors01:19

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors

α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
905