Related Experiment Video

Updated: Apr 12, 2026

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
08:16

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

Published on: March 16, 2022

4.2K

Infective gangrene in extremity trauma-are we targeting the right organisms?

Rajat Thawani1, Seema Singh2, Sonal Sharma3

  • 1University College of Medical Sciences, Delhi, India.

The Indian Journal of Surgery
|May 15, 2015
PubMed

Insights

Mucormycosis, a rare fungal infection, can cause gangrene even after closed fractures in at-risk patients. Early diagnosis via tissue examination and prompt antifungal treatment are crucial for managing this severe condition.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Dermatology

Background:

  • Mucormycosis is a rare, fatal fungal infection caused by Zygomycetes.
  • It typically affects immunocompromised and diabetic individuals.
  • The infection is often linked to open fractures in at-risk patients.

Purpose of the Study:

  • To report a case of cutaneous mucormycosis leading to gangrene following a closed fracture.
  • To highlight the importance of considering mucormycosis in antibiotic-resistant wound infections, even in closed injuries.

Main Methods:

  • Case report of cutaneous mucormycosis.
  • Histopathological and microbiological examination of tissue from surgical debridement.
  • Review of clinical presentation and management.

Main Results:

  • Cutaneous mucormycosis developed into gangrene after a closed fracture.
  • The condition was diagnosed through tissue examination.

Conclusions:

  • Mucormycosis should be considered in the differential diagnosis of wound infections unresponsive to antibiotics, including those from closed injuries.
  • Early diagnosis through tissue analysis, surgical intervention, and parenteral antifungal therapy are essential for effective management.
Keywords:
FungusGangreneMucormycosisTrauma

Related Concept Videos

Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
5.0K
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
596
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
600
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
855
Veins of Lower Limbs01:15

Veins of Lower Limbs

The human body consists of an intricate network of veins responsible for the crucial task of blood drainage from the lower limbs. These veins can be categorized into two main types: deep veins and superficial veins.
Formed by the union of the medial and lateral plantar veins, the posterior tibial vein, rising through the calf muscle, assimilates the fibular vein. The anterior tibial vein, a superior extension of the foot's dorsalis pedis vein, merges with the posterior tibial vein at the...
3.2K
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
606