Abnormal karyotypes in osteochondroma: Case series and literature review

Osteochondroma is the most common benign bone tumor. However, there are infrequent studies karyotyping solitary osteochondromas.

Retrospective review of the University of California, Los Angeles pathology database was performed for karyotype analyses (N = 522 specimens).

Two previously undescribed karyotypes were identified. First, was a karyotype showing paracentric inversion of chromosome 7. Second, was a karyotype showing monosomy 3, 6 and 13.

Abnormal karyotypes may be more frequently encountered in osteochondroma than previously understood. However, the clinical significance of these abnormalities are yet unknown.