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Published on: September 12, 2019
Targeting gallbladder cancer: hyaluronan sensitizes cancer cells to chemo-therapeutics
Mingzhe Ma1, Mingzhe Weng2, Mingdi Zhang2
1Department of General Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine Shanghai, China ; Department of General Surgery, Taixing People's Hospital, Yangzhou University School of Medicine Jiangsu Province, China.
Abstract:
Gallbladder cancer is the most common biliary tract malignancy and the fifth most common gastrointestinal malignancy. Chemo-resistance is the most remarkable characteristic of gallbladder cancer. The relatively dense extracellular space in tumor is the main barrier to nanotherapeutics' anticancer efficacy. Hyaluronan (HA) was shown in our previous study to significantly improve the myxoma virus distribution via promoting the MMP-9 production, which degrades collagen IV. We demonstrated that HA increased the chemo-sensitivity of gallbladder cancer cells both in vitro and in vivo. The in vivo chemo-sensitization effect of HA could partially be due to the penetration-promoting effect of HA via degrading collagen IV.
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