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Subependymoma with extensive microcystic transformation: a case report
1Department of Pathology, 251 Hospital of PLA Zhangjiakou 075000, China.
Summary
Subependymomas, rare benign brain tumors, can present as large masses compressing critical structures. Complete surgical removal of this subtentorial subependymoma resulted in no recurrence, highlighting successful treatment outcomes.
Area of Science:
- Neuropathology
- Neurosurgery
- Oncology
Background:
- Subependymomas are rare, slow-growing tumors typically arising within the brain's ventricular system.
- They are often asymptomatic until reaching a size that causes mass effect or obstructive hydrocephalus.
Observation:
- A case report details a 44-year-old female presenting with a large subtentorial mass.
- The mass significantly compressed the brainstem and fourth ventricle, indicating a critical location.
Findings:
- Histopathological examination revealed a tumor composed of cytologically bland cells with fibrillar matrix and microcystic changes.
- Immunohistochemistry showed positivity for GFAP and S-100 protein, with low MIB-1 proliferation index (<1%), consistent with subependymoma.
- The tumor exhibited patchy Epithelial Membrane Antigen expression and negative staining for Neu-N and Progesterone receptor.
Implications:
- Complete surgical excision was successfully achieved, offering a curative option for this type of brain tumor.
- The lack of tumor recurrence post-surgery suggests favorable long-term prognosis following complete resection.
- This case contributes to understanding the clinical presentation, histopathology, and surgical management of subtentorial subependymomas.
