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Updated: Apr 12, 2026

Author Spotlight: Decoding Mitochondrial Aging
Published on: June 30, 2023
Alzheimer's pathogenesis and its link to the mitochondrion
C Simoncini1, D Orsucci1, E Caldarazzo Ienco1
1Department of Experimental and Clinical Medicine, Neurological Clinic, University of Pisa, Via Roma 67, 56126 Pisa, Italy.
Abstract:
Alzheimer's disease (AD) is the most common form of dementia in the elderly. This neurodegenerative disorder is clinically characterized by impairment of cognitive functions and changes in behaviour and personality. The pathogenesis of AD is still unclear. Recent evidence supports some role of mitochondria dysfunction and oxidative stress in the development of the neurodegenerative process. In this review, we discuss the role of mitochondrial dysfunction in AD, focusing on the mechanisms that lead to mitochondrial impairment, oxidative stress, and neurodegeneration, a "vicious circle" that ends in dementia.
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