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Published on: July 25, 2020
Dermatology update: The dawn of targeted treatment
1Director of Medical and Inpatient Dermatology, Department of Dermatology, and Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA.
Abstract:
During the past several years, targeted therapies have significantly improved outcomes in advanced basal cell carcinoma, psoriasis, and metastatic melanoma. This article reviews how advances in our understanding of the molecular pathogenesis of these diseases led to the development of targeted therapies and how these therapies are improving outcomes. Research is ongoing to address continuing challenges of drug resistance, adverse effects, and how best to use the new medications.
Insights
Targeted therapies have transformed advanced basal cell carcinoma, psoriasis, and metastatic melanoma treatment. Ongoing research aims to overcome drug resistance and side effects for better patient outcomes.
Area of Science:
- Oncology
- Dermatology
- Molecular Biology
Background:
- Review of targeted therapies for advanced basal cell carcinoma, psoriasis, and metastatic melanoma.
- Focus on molecular pathogenesis driving therapeutic development.
Observation:
- Significant improvements in patient outcomes observed with targeted therapies.
- Advances in understanding disease mechanisms have enabled targeted treatment strategies.
Findings:
- Targeted therapies have demonstrated efficacy in treating advanced basal cell carcinoma, psoriasis, and metastatic melanoma.
- Molecular insights are crucial for developing effective targeted treatments.
Implications:
- Continued research is essential to address challenges like drug resistance and adverse effects.
- Optimizing the use of novel targeted medications is a key area for future clinical practice.
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