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Quantitative proteomic analysis reveals that anti-cancer effects of selenium-binding protein 1 in vivo are associated

Qi Ying1, Emmanuel Ansong2, Alan M Diamond2

  • 1College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China; Department of Pathology, Xinxiang Medical University, Xinxiang, 453003, China; Department of Pathology, University of Illinois at Chicago, Chicago, Illinois 60612, United States of America.

Plos One
|May 15, 2015
PubMed

Insights

Selenium-binding protein 1 (SBP1) inhibits colorectal cancer growth and metastasis. This study reveals SBP1 alters lipid/glucose metabolism and related signaling pathways, uncovering a novel anti-cancer mechanism.

Area of Science:

  • Oncology
  • Molecular Biology
  • Metabolomics

Background:

  • Selenium-binding protein 1 (SBP1) is known for its tumor-suppressive functions.
  • The precise molecular mechanisms behind SBP1's anti-cancer effects remain largely unelucidated.

Purpose of the Study:

  • To investigate the mechanisms of SBP1-mediated tumor suppression in colorectal cancer.
  • To identify proteins and pathways affected by SBP1 induction.

Main Methods:

  • Induction of SBP1 in colorectal cancer models.
  • Isobaric tags for relative and absolute quantitation (iTRAQ) for proteomic analysis of tumor tissues.
  • Bioinformatic analysis of differentially expressed proteins and associated signaling pathways.

Main Results:

  • SBP1 induction significantly inhibited colorectal cancer cell growth and metastasis in vivo.
  • iTRAQ identified 132 differentially expressed proteins (53 upregulated, 79 downregulated).
  • Altered proteins were predominantly involved in lipid/glucose metabolism and linked to Glycolysis, MAPK, Wnt, NF-kB, NOTCH, and EMT signaling.

Conclusions:

  • SBP1 exerts anti-cancer effects by modulating lipid and glucose metabolic pathways.
  • This study reveals a novel mechanism of SBP1-mediated colorectal cancer inhibition.
  • Targeting SBP1 or its downstream metabolic pathways may offer new therapeutic strategies for colorectal cancer.

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