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Related Experiment Videos

One year's experience using a rotating filter for therapeutic plasma exchange.

A A Kaplan1, S E Halley, J Reardon

  • 1Department of Medicine, University of Connecticut Health Center, Farmington 06032.

ASAIO Transactions
|July 1, 1989
PubMed
Summary

This study shows a rotating filter system is effective for therapeutic plasma exchange, removing large volumes of plasma efficiently with minimal complications. The system

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Area of Science:

  • Biomedical Engineering
  • Nephrology
  • Hematology

Background:

  • Previous work established the feasibility of a rotating filter system for therapeutic plasma exchange.
  • This study details the clinical application and outcomes of this system over one year.

Purpose of the Study:

  • To report on the technical aspects and clinical experience of using a rotating filter system for therapeutic plasma exchange.
  • To evaluate the efficiency, safety, and potential limitations of the rotating filter system.

Main Methods:

  • Seventeen patients received 188 therapeutic plasma exchange treatments using the rotating filter system.
  • Hemoaccess was achieved via antecubital veins, femoral catheters, or an arteriovenous fistula.
  • Blood flow rates, plasma removal volumes, treatment times, and platelet counts were monitored.

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Main Results:

  • The system achieved a mean plasma removal rate of 40.2 mL/min with a mean treatment time of 83 minutes.
  • A 15% decline in platelet count was observed post-treatment, with no significant membrane plugging or hemolysis noted.
  • In a cascade system for cholesterol removal, efficiency decreased and treatment time increased compared to a single-pass system.

Conclusions:

  • The inexpensive rotating filter system provides highly efficient therapeutic plasma exchange.
  • The system's inherent efficiency requires consideration when used with secondary filtration techniques, such as for cholesterol removal.