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Therapeutic Challenges in Diabetes Prevention: We Have Not Found the "Exercise Pill"
S Srinivasan1,2,3,4, J C Florez3,5,6,4
1Pediatric Endocrine Unit, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.
Abstract:
Type 2 diabetes has become an enormous public health burden, making diabetes prevention a pressing issue. While lifestyle modification is the most effective preventive strategy, it is resource-intensive and not universally sustainable. We review the evidence on pharmacological options for diabetes prevention, in search of a medication that is efficacious, easy to adhere to, well tolerated, and cost-effective. With the exception of metformin, most other drugs have either limited efficacy or costly side effects.
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