Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Computer model of ventricular interaction during left ventricular circulatory support.

J C Woodard¹, D J Farrar, E Chow

¹Department of Cardiovascular Surgery, Pacific Presbyterian Medical Center, San Francisco, California.

ASAIO Transactions

|July 1, 1989

Summary

Computer models show that ventricular interactions can impair or improve right ventricular (RV) function during left ventricular assist device (LVAD) use. However, these effects largely cancel out in a healthy heart.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Immediate Effects of Transcatheter Aortic Valve Replacement on Left Ventricular Cardiac Mechanics in Moderate Aortic Stenosis: A Case Series With In Vivo Pressure-Volume Reconstructions.

Journal of cardiac failure·2025

Same author

The maximum dose of atorvastatin and simvastatin as well as rosuvastatin should be restricted in East Asians.

Hong Kong medical journal = Xianggang yi xue za zhi·2024

Same author

Resting and exercise haemodynamic characteristics of patients with advanced heart failure and preserved ejection fraction.

ESC heart failure·2021

Same author

Cardiac arrhythmias and electrophysiologic responses during spontaneous hyperglycaemia in adults with type 1 diabetes mellitus.

Diabetes & metabolism·2021

Same author

CCTG SC.24/TROG 17.06: A Randomized Phase II/III Study Comparing 24Gy in 2 Stereotactic Body Radiotherapy (SBRT) Fractions Versus 20Gy in 5 Conventional Palliative Radiotherapy (CRT) Fractions for Patients with Painful Spinal Metastases.

International journal of radiation oncology, biology, physics·2021

Same author

Bone health in cancer: ESMO Clinical Practice Guidelines.

Annals of oncology : official journal of the European Society for Medical Oncology·2020

Area of Science:

Cardiovascular physiology
Computational modeling
Medical device research

Background:

Right ventricular (RV) failure is a concern during left ventricular assist device (LVAD) therapy.
The role of anatomic ventricular interactions in RV function during LVAD support is not fully understood.

Purpose of the Study:

To investigate the hypothesis that anatomic ventricular interactions are responsible for RV failure during LVAD use.
To elucidate the mechanisms by which ventricular interactions influence RV function in the context of LVAD support.

Main Methods:

Development and utilization of a sophisticated computer model of the heart and circulatory system.
Simulation of LVAD implantation and its effects on ventricular pressure dynamics.
Analysis of simulated RV function under varying conditions of systolic and diastolic ventricular interaction.

Related Experiment Videos

Main Results:

The model predicts that LVAD-induced pressure unloading impairs RV function with isolated systolic interaction.
Conversely, isolated diastolic interaction improves RV function.
The competing effects of systolic and diastolic interactions result in a negligible overall impact on RV function in the normal heart.

Conclusions:

Anatomic ventricular interactions play a complex role in RV function during LVAD therapy.
The net effect of these interactions on RV function is minimal in a healthy heart due to opposing influences.
Further research may be needed to understand RV adaptation in diseased hearts during LVAD support.