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An ambulatory, intermediate term left ventricular assist device.

V L Poirier1, C W Sherman, W C Clay

  • 1Thermo Cardiosystems Inc., Woburn, Massachusetts 01888-2697.

ASAIO Transactions
|July 1, 1989
PubMed
Summary
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This study details a portable ventricular assist device for long-term use. The device showed satisfactory performance in vitro and in vivo, with observations of hypertension and vascular changes in implants.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Devices
  • Implantable Technology

Background:

  • Left ventricular assist devices (LVADs) are crucial for managing advanced heart failure.
  • Current devices face challenges in portability and long-term biocompatibility.
  • Development of improved percutaneous, battery-operated LVADs is essential.

Purpose of the Study:

  • To describe a novel portable, percutaneous, battery-operated left ventricular assist device.
  • To evaluate the in vitro and in vivo performance of this new LVAD system.
  • To assess the biocompatibility and potential complications associated with intermediate and long-term use.

Main Methods:

  • In vitro testing of the LVAD system for up to 9 months.
  • In vivo implantation studies in animal models for over 3 months.

Related Experiment Videos

  • Histopathological examination of blood pump surfaces and associated tissues.

    • Main Results:

    • The LVAD system demonstrated satisfactory performance in vitro and in vivo.
    • Long-standing hypertension and associated renal/visceral vascular changes were observed in a 98-day implant.
    • No peripheral thromboembolism was detected; biologic lining formed on the pump surface with some peripheral calcification.

    Conclusions:

    • The described portable LVAD shows promise for intermediate and long-term support.
    • Further investigation is needed to address observed hypertension and vascular changes.
    • Biocompatibility appears adequate, with potential for surface modification to mitigate calcification.