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Potassium dehydroandrographolide succinate injection for treat- ment of infantile pneumonia: a systematic review and

Zhang Xiaomeng, Wu Jiarui, Zhang Bing

    Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan
    |May 16, 2015
    PubMed

    Insights

    Potassium dehydroandrographolide succinate injection (PDS) is effective and safe for treating infantile pneumonia, improving recovery times and symptoms. Higher quality studies are needed to confirm these findings for PDS efficacy.

    Area of Science:

    • Pediatrics
    • Pharmacology
    • Evidence-Based Medicine

    Background:

    • Infantile pneumonia is a common respiratory infection in children.
    • Potassium dehydroandrographolide succinate injection (PDS) is a potential therapeutic agent.
    • Systematic evaluation of PDS for infantile pneumonia is warranted.

    Purpose of the Study:

    • To systematically evaluate the clinical efficacy and safety of PDS in treating infantile pneumonia.
    • To synthesize evidence from randomized controlled trials (RCTs).

    Main Methods:

    • Searched multiple databases for RCTs of PDS in infantile pneumonia (1979-2013).
    • Assessed study quality using Cochrane risk of bias tool.
    • Conducted a meta-analysis using Review Manager 5.2.

    Main Results:

    • Included 9 RCTs with 1056 participants; study quality was generally low.
    • PDS significantly improved total effective rate (RR=1.21) compared to conventional therapy.
    • PDS reduced temperature recovery time (MD=-1.43) and improved rale disappearance and cough relief (MD=-1.44).
    • Adverse drug reactions (rash, diarrhea) were reported but not serious.

    Conclusions:

    • PDS demonstrates efficacy and relative safety for infantile pneumonia treatment.
    • The quality of included studies is a limitation.
    • Further high-quality RCTs are recommended to confirm PDS efficacy and safety.
    Abstract

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