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Related Experiment Videos

Left ventricular function in patients with centrifugal left ventricular assist device.

M S Verani1, M E Sekela, J J Mahmarian

  • 1Department of Medicine, Baylor College of Medicine, Houston, Texas 77030.

ASAIO Transactions
|July 1, 1989
PubMed
Summary

Patients with assist devices (AD) for left ventricular (LV) dysfunction showed improved LV ejection fraction (EF) when AD flow was reduced. Weaning success correlated with EF improvement, indicating AD flow optimization is key for recovery.

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Area of Science:

  • Cardiology
  • Biomedical Engineering

Background:

  • Severe left ventricular (LV) dysfunction often necessitates mechanical circulatory support.
  • Centrifugal assist devices (AD) are used to manage postoperative LV dysfunction.

Purpose of the Study:

  • To evaluate the impact of assist device (AD) flow on left ventricular (LV) ejection fraction (EF) and patient outcomes.
  • To determine if changes in LV-EF with varying AD flows correlate with successful weaning and long-term survival.

Main Methods:

  • Blood pool radionuclide angiography was used to assess LV ejection fraction (EF) in 17 patients with centrifugal assist devices (AD).
  • LV-EF was measured during maximal and minimal AD flows, and during maximal LVAD flow rates.

Main Results:

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  • Patients weaned from the AD had a higher LV-EF during maximal flow compared to those who could not be weaned (18% vs. 9%, p=0.04).
  • In patients who could be weaned, decreasing AD flow from maximal to minimal significantly increased LV-EF (15% to 33%, p<0.005).
  • Long-term survivors demonstrated a substantial increase in LV-EF with decreased AD flow (182% increase), unlike short-term survivors (44% increase).

    • Conclusions:

    • Optimizing assist device (AD) flow by reducing it can significantly improve left ventricular (LV) ejection fraction (EF).
    • The ability to increase LV-EF by adjusting AD flow is a strong indicator of successful weaning and long-term survival in patients with LV dysfunction.