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[Impacts of hypertension on early changes of cardiovascular structure and function among children: a case-control

Qin Liu1, Hongbo Dong2, Linghui Meng1

  • 1Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China.

Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi
|May 16, 2015
PubMed

Insights

Pediatric primary hypertension is linked to left ventricular remodeling and early functional changes, even in children under 12. Vascular structure and function show no significant differences in these young patients.

Area of Science:

  • Cardiology
  • Pediatric Hypertension
  • Cardiovascular Health

Background:

  • Primary hypertension in children is a growing concern.
  • Understanding its impact on cardiovascular structure and function is crucial for early intervention.

Purpose of the Study:

  • To assess cardiovascular structure and function in children with primary hypertension.
  • To explore the influence of hypertension and related risk factors on these parameters.

Main Methods:

  • Cardiac and vascular parameters were measured in 213 hypertensive children and 197 healthy controls.
  • Measurements included left ventricular dimensions, mass, and vascular indices like carotid intima-media thickness and pulse wave velocity.

Main Results:

  • Hypertensive children exhibited significantly higher left ventricular mass (LVM) and left ventricular mass index (LVMI).
  • No significant differences were observed in carotid intima-media thickness (cIMT) or relative wall thickness (RWT).
  • LVMI correlated with age, sex, BMI, and hypertension; RWT correlated with age and BMI.

Conclusions:

  • Children with primary hypertension show left ventricular remodeling and early functional changes, particularly those under 12.
  • No significant changes in vascular structure or function were detected in this cohort.
Abstract

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