Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A novel approach to anticoagulation control.

J S Kim1, C Vincent, C L Teng

  • 1College of Pharmacy, University of Michigan, Ann Arbor 48109-1065.

ASAIO Transactions
|July 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnosis and treatment of benign paroxysmal positional vertigo with lateral canal involvement.

European annals of otorhinolaryngology, head and neck diseases·2025
Same author

Speech audiometry in noise: Signal noise ratio loss values according speech signal level presentation in normal hearing subjects.

European annals of otorhinolaryngology, head and neck diseases·2025
Same author

Binaural performance in 155 adults with single-sided or asymmetric profound hearing loss: A STROBE analysis.

European annals of otorhinolaryngology, head and neck diseases·2025
Same author

Comparative analysis of underwater acoustic propagation models: Evaluating the trade-off between accuracy and computational demands for coastal noise predictions.

Marine pollution bulletin·2025
Same author

Near-infrared optical thermometry of nickel color centers in diamond.

Optics letters·2025
Same author

External auditory canal chondroid syringoma with bone erosion: A CARE case report.

European annals of otorhinolaryngology, head and neck diseases·2024

A novel protamine filter effectively neutralizes heparin anticoagulant activity during extracorporeal therapy, minimizing bleeding risks and adverse hemodynamic effects. This innovation also reduces protamine-induced thrombocytopenia and complement activation.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Hematology

Background:

  • Heparin anticoagulation in extracorporeal therapy frequently causes bleeding complications.
  • Protamine sulfate, used for heparin reversal, can induce adverse hemodynamic responses.
  • Existing methods for heparin management present significant risks.

Purpose of the Study:

  • To develop and evaluate a cellulosic hollow-fiber filter device with immobilized protamine for safe heparin reversal.
  • To assess the efficacy of the protamine filter in removing heparin's anticoagulant activity.
  • To investigate the hemodynamic and hematologic safety profile of the protamine filter.

Main Methods:

  • Development of a hollow-fiber filter device incorporating immobilized protamine.

Related Experiment Videos

  • In vivo studies using a canine model to evaluate filter performance.
  • Measurement of heparin removal, hemodynamic parameters, and hematologic responses (thrombocytopenia, granulocytopenia).
  • Assessment of complement system activation.

    • Main Results:

    • The protamine filter removed over 80% of heparin's anticoagulant activity.
    • No clinically significant adverse hemodynamic responses were observed.
    • The filter significantly attenuated thrombocytopenic and granulocytopenic responses.
    • Immobilized protamine substantially reduced complement system activation compared to free protamine.

    Conclusions:

    • The protamine filter offers a safe and effective method for heparin reversal in extracorporeal circuits.
    • This device mitigates bleeding complications and adverse hemodynamic effects associated with heparin and protamine.
    • The immobilized protamine approach minimizes protamine-induced hematologic and immunologic complications.