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Related Experiment Videos

Residence time distributions in artificial ventricles.

U R Shettigar1, M Dropmann, P E Christian

  • 1Kolff's Laboratory, Department of Surgery, University of Utah, Salt Lake City 84112.

ASAIO Transactions
|July 1, 1989
PubMed
Summary

This study introduces residence time distribution (RTD) analysis for artificial ventricles. Preliminary findings show significant blood element retention and backflow influenced by valve type and orientation.

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Device Research
  • Hemodynamics

Background:

  • Blood element residence time in artificial ventricles impacts exposure to damaging factors.
  • Understanding flow dynamics is crucial for improving artificial heart performance.
  • Previous studies lacked detailed residence time distribution (RTD) analysis for artificial ventricles.

Purpose of the Study:

  • To investigate the residence time distribution (RTD) in an artificial ventricle.
  • To evaluate the influence of different valve types (Bjork-Shiley and polyurethane) and orientations on RTD.
  • To quantify blood element washout and retention within the artificial ventricle.

Main Methods:

  • Construction of an open-loop mock circulation system simulating left ventricular flow and pressure.
  • Development of a drive-triggered injection unit for tracer introduction during diastole.
  • Utilized Tc-99m radionuclide and chemical tracers for RTD studies.
  • Employed a scintillation camera to visualize backflow and intraventricular washout.

Main Results:

  • 42% of fluid elements were expelled after the first beat, with 58% retained.
  • Subsequent beats expelled retained elements: 36% in the second beat, 17% in the third, and 5% in later beats.
  • Residence time distribution varied significantly with the positioning of Bjork-Shiley valves.

Conclusions:

  • The study provides novel preliminary data on artificial ventricle RTD.
  • Valve type and orientation demonstrably affect intraventricular flow patterns and blood element retention.
  • Findings highlight the importance of valve design and placement for optimizing artificial ventricle function and minimizing blood damage.

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