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Related Experiment Video

Updated: Apr 12, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Depression during Pregnancy.

Teri Pearlstein1

  • 1Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA; Women's Behavioral Medicine, Women's Medicine Collaborative, 146 West River Street, Providence, RI 02904, USA.

Best Practice & Research. Clinical Obstetrics & Gynaecology
|May 16, 2015
PubMed
Summary

Managing psychiatric disorders during pregnancy requires careful consideration. Untreated maternal depression and antidepressant use pose risks to birth outcomes and child development, necessitating evidence-based treatment strategies.

Keywords:
antidepressantcongenital malformationdepressionmiscarriagepersistent pulmonary hypertension of the newbornpregnancy

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Area of Science:

  • Obstetrics and Gynecology
  • Perinatal Psychiatry
  • Developmental Pediatrics

Background:

  • Pregnancy often involves women with active psychiatric conditions, with or without psychotropic medication.
  • Untreated antenatal depression and stress are linked to adverse birth outcomes and child development.
  • Antenatal exposure to antidepressant medications also presents potential risks to pregnancy and development.

Purpose of the Study:

  • To review best practices for managing depression in pregnant women.
  • To highlight the risks associated with untreated depression and antidepressant use during pregnancy.
  • To provide recommendations for future research in perinatal mental health.

Main Methods:

  • Systematic review of existing literature.
  • Meta-analysis of relevant studies.
  • Synthesis of current evidence on perinatal psychiatric care.

Main Results:

  • Antidepressant use in pregnancy is associated with small increased risks of miscarriage, cardiac malformations, preterm birth, and persistent pulmonary hypertension of the newborn (PPHN).
  • Transient neonatal symptoms occur in up to one-third of neonates exposed to antidepressants.
  • There is a possible increased risk of delayed motor development in children exposed antenatally to antidepressants.

Conclusions:

  • Current evidence provides minimal definitive conclusions to guide treatment recommendations for depression in pregnancy.
  • Management strategies must weigh the risks of untreated maternal illness against potential medication side effects.
  • Further research is crucial to establish clear guidelines for safe and effective perinatal mental health care.