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Updated: Apr 12, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
The genetic basis of uveal melanoma
M Nielsen1, M Dogrusöz2, J C Bleeker2
1Department of clinical genetics, Building 1, K5-R, LUMC, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.
Abstract:
Uveal melanoma (UM) is the most common intraocular malignancy in adults with an incidence of about 1/100,000 new cases per year in the Western world. Risk factors are having a light skin, blond hair and blue eyes. As some UM patients have a young age at diagnosis or an affected family history for UM or other malignancies, there may be an underlying genetic basis. This review discusses known or suspected risk factors for UM, the cancer risk in UM patients and their family members, and the genes that have been reported to predispose to UM (germline mutations) and tumor development (somatic mutations).
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