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Quetiapine-induced hypertriglyceridaemia causing acute pancreatitis.
John Mark Franco1, Saraschandra Vallabhajosyula1, Timothy John Griffin2
1Department of Internal Medicine, Creighton University School of Medicine, Omaha, Nebraska, USA.
BMJ Case Reports
|May 16, 2015
Summary
Second-generation antipsychotics like quetiapine can cause severe metabolic side effects. This case highlights acute pancreatitis, hypertriglyceridemia, hyperglycemia, and neutropenia linked to quetiapine use.
Area of Science:
- Pharmacology
- Gastroenterology
- Hematology
Background:
- Second-generation antipsychotics are associated with metabolic side effects, including hyperlipidemia and hyperglycemia.
- Quetiapine, an atypical antipsychotic, has been rarely linked to acute pancreatitis.
Purpose of the Study:
- To report a rare case of acute pancreatitis, severe hypertriglyceridemia, hyperglycemia, and neutropenia potentially caused by quetiapine.
- To emphasize the importance of considering drug-induced causes in patients presenting with these symptoms.
Main Methods:
- A middle-aged male patient presented with symptoms of acute pancreatitis and was found to have significantly elevated triglycerides, lipase, and glucose levels.
- Hematological evaluation revealed neutropenia with pancytopenia.
- The patient was managed with conservative treatment, insulin, and lipid-lowering agents, and later transitioned to ziprasidone.
Main Results:
- The patient experienced severe hypertriglyceridemia (3590 mg/dL), hyperglycemia, and neutropenia.
- Quetiapine was suspected as the causative agent due to the combination of symptoms.
- The patient's condition improved with treatment, and his laboratory values normalized upon discharge.
Conclusions:
- This case underscores the potential for quetiapine to induce severe metabolic disturbances and acute pancreatitis.
- Clinicians should maintain a high index of suspicion for drug-induced pancreatitis in patients with unexplained metabolic abnormalities.
- Early recognition and management are crucial for favorable outcomes in such cases.
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