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Structure and Function of Platelets

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Updated: Apr 12, 2026

Microfluidics in Assessing Platelet Function

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Laboratory testing for platelet function disorders.

¹Department of Pediatrics and Child Health, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada.

International Journal of Laboratory Hematology

|May 16, 2015

Summary

This summary is machine-generated.

Evaluating platelet function disorders requires a stepwise approach. This involves clinical assessment, platelet counts, and morphology, followed by specialized tests like aggregometry for accurate diagnosis and optimized lab resource use.

Keywords:

Platelet disorders clinical laboratory techniques/standards platelet aggregation platelet function tests thrombocytopenia

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Microfluidics in Assessing Platelet Function

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Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

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Published on: May 2, 2025

Area of Science:

Hematology
Clinical Pathology
Diagnostic Laboratory Science

Background:

Platelet function testing is complex and resource-intensive.
Accurate diagnosis of platelet disorders is crucial for patient management.
Standardized laboratory approaches are needed to ensure reliable results.

Purpose of the Study:

To outline a stepwise approach for evaluating suspected platelet disorders.
To optimize laboratory resource utilization in platelet function testing.
To review available diagnostic methods for clinical laboratories.

Main Methods:

Initial clinical evaluation including bleeding assessment tools.
Review of platelet counts and peripheral blood cell morphology.
Subsequent laboratory testing: platelet aggregometry, secretion assays, von Willebrand factor assays, flow cytometry, electron microscopy, and molecular diagnostics.

Main Results:

A stepwise diagnostic strategy guides laboratory testing effectively.
Standardized testing protocols, particularly for light transmission aggregometry, improve diagnostic accuracy.
Integration of clinical and laboratory findings ensures comprehensive patient evaluation.

Conclusions:

A structured, stepwise approach enhances the diagnosis of platelet function disorders.
Standardization of platelet function tests is essential for quality assurance.
This review provides a framework for clinical laboratories to optimize diagnostic workflows.