Versatile pulse sequence device to conserve hyperpolarization for NMR and MRI studies.

Area of Science:

• Magnetic Resonance Imaging
• Quantum Information Science

Background:

• The M2S pulse sequence facilitates spin order transfer between longitudinal and singlet states.
• Increasing the relaxation time of polarized compounds is crucial for enhancing signal detection in various applications.

Purpose of the Study:

• To construct a portable M2S pulse sequence generator for extending polarized compound relaxation times.
• To investigate the efficiency of spin order transfer with imprecise physical parameters.

Main Methods:

• Development of a portable M2S generator.
• Conversion of longitudinally polarized N2O to the singlet state using adiabatic transfer and M2S sequence.
• Density matrix simulations to model parameter mismatch effects.

Main Results:

• Simulations indicate precise calibration of Larmor frequency (10%), scalar couplings (<0.6%), and flip angle (<2%) is needed for 95% conversion.
• The M2S sequence demonstrates robustness against variations in physical parameters.

Conclusions:

• The portable M2S generator effectively increases the lifetime of hyperpolarized species by approximately 12-fold.
• The instrument's portability allows for on-site conversion of hyperpolarized compounds near the polarizer.
• This technology is highly beneficial for systems with rapidly relaxing hyperpolarized media.