Related Experiment Video

Updated: Apr 12, 2026

High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease
09:00

High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease

Published on: October 31, 2012

16.4K

Can be galectin-3 a novel marker in determining mortality in hemodialysis patients?

Gulsum Ozkan1, Sukru Ulusoy2, Ahmet Menteşe3

  • 1Department of Nephrology, Hatay Antakya State Hospital, Hatay, Turkey.

Clinical Biochemistry
|May 16, 2015
PubMed

Insights

This study found that higher galectin-3 levels are linked to increased cardiac mortality in hemodialysis patients, suggesting it as a potential new biomarker for cardiovascular risk stratification.

Area of Science:

  • Nephrology
  • Cardiology
  • Biomarkers

Background:

  • Cardiovascular mortality is a significant concern for patients undergoing hemodialysis (HD).
  • Assessing cardiovascular (CV) risk in HD patients presents challenges.
  • Galectin-3, a known predictor of heart failure (HF) risk and CV mortality, has not been studied in this population.

Purpose of the Study:

  • To investigate the relationship between galectin-3 levels and cardiac mortality in hemodialysis patients.
  • To explore galectin-3 as a potential biomarker for cardiac mortality in this specific patient group.

Main Methods:

  • A multi-center, prospective, observational study involving 290 clinically stable HD patients and 30 healthy controls.
  • Patients were monitored for 24 months, with baseline galectin-3 and biochemical parameters measured.
  • Statistical analysis, including multivariate Cox regression, was used to identify mortality predictors.

Main Results:

  • Hemodialysis patients exhibited significantly higher galectin-3 levels compared to controls (p < 0.001).
  • Galectin-3 was identified as a significant prognostic determinant for both all-cause mortality and cardiac mortality in multivariate analysis.
  • Other identified predictors included age, low albumin, low diastolic blood pressure, and high C-reactive protein for all-cause mortality; and age, low albumin, and high systolic blood pressure for cardiac mortality.

Conclusions:

  • Galectin-3 emerges as a novel potential biomarker for predicting cardiac mortality in hemodialysis patients.
  • Further research is warranted to validate galectin-3's role in cardiovascular risk stratification for HD patients.
Abstract

Keywords:
Cardiac mortalityGalectin 3HemodialysisMortality

More Related Videos

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis05:28

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

4.8K

Related Concept Videos

Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
1.6K
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
1.5K
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
645
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
119
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
3.5K
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
515