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Updated: Apr 12, 2026

Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg
Published on: November 19, 2019
Antibiotic Prophylaxis in Autologous Vein Graft Reconstructions of the Lower Extremity
Jeroen Jongkind1, Çaĝdaş Ünlü2, Anco Vahl3
1Sint Lucas Andreas Ziekenhuis, Department of Vascular Surgery, Vascular Centre Amsterdam, Amsterdam, the Netherlands jeroenjongkind@hotmail.com.
Background:
Different factors contribute to infection after arterial reconstructive surgery. Prophylactic antibiotic use during surgery is widespread, however, there is insufficient evidence to support the use of prophylactic antibiotics with autologous vein grafting. The aim of our study was to assess the effect of single-dose prophylactic antibiotics in patients undergoing autologous vein grafting.
Methods:
Patients undergoing arterial bypass reconstruction in the lower extremity between 2004 and 2012 were retrospectively screened for use of vein grafts. Patients receiving single-dose antibiotic prophylaxis (group 1) were compared with those not receiving prophylaxis (group 2).
Results:
Primary outcome was surgical site infection (SSI), and 142 patients were included. The SSI occurred in 22% of patients in group 1 and in 29% of patients in group 2 (P = .39; odds ratio: 1.46 confidence interval 95%: 0.61-3.47).
Conclusions:
Results showed no significant effect from single-dose antibiotic prophylaxis on lowering the incidence of SSI.
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