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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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Related Experiment Video

Updated: Apr 12, 2026

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
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Red cell and platelet transfusions in neonates: a population-based study.

Jennifer R Bowen1, Jillian A Patterson2, Christine L Roberts2

  • 1Department of Neonatology, Royal North Shore Hospital, St Leonards, New South Wales, Australia University of Sydney, Sydney, New South Wales, Australia.

Archives of Disease in Childhood. Fetal and Neonatal Edition
|May 16, 2015
PubMed
Summary

Neonatal transfusions for red cells, platelets, and exchange were analyzed in a large Australian cohort. While preterm infants received more transfusions, a significant portion were born at or after 32 weeks gestation.

Keywords:
EpidemiologyHaematologyNeonatology

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Area of Science:

  • Neonatal Medicine
  • Hematology
  • Public Health

Background:

  • Neonatal transfusions are critical for managing various conditions in newborns.
  • Understanding transfusion trends and rates in a population is essential for resource allocation and guideline development.

Purpose of the Study:

  • To describe red cell, platelet, and exchange transfusion use in a population-based cohort of neonates.
  • To examine trends in neonatal transfusion rates over time (2001-2011).
  • To determine transfusion rates in neonates at high risk, including those born prematurely or with specific conditions.

Main Methods:

  • Utilized linked population-based birth and hospital data from New South Wales (NSW), Australia.
  • Included all live births from ≥23 weeks' gestation between 2001 and 2011.
  • Calculated rates of red cell, platelet, and exchange transfusions within the first 28 days of life.

Main Results:

  • Over 5300 neonates received transfusions (5.4/1000 births) between 2001-2011.
  • Transfusion rates remained stable; preterm infants (<32 weeks) had higher rates, but 40% of transfused neonates were ≥32 weeks gestation.
  • Higher transfusion rates were associated with in utero transfusion, congenital anomalies requiring surgery, and hemolytic disorders.

Conclusions:

  • Preterm neonates exhibit higher transfusion rates, but a substantial proportion of transfusions occur in later-gestation infants.
  • A notable percentage of neonates (7%) received transfusions in hospitals lacking a neonatal intensive care unit (NICU).
  • Findings necessitate consideration by transfusion services and guideline developers for optimizing neonatal transfusion practices.