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Maspin highlights colorectal serrated polyps: preliminary findings
Carlos A Rubio1, Ann Kaufeldt2
1Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden Carlos.Rubio@ki.se.
In Vivo (Athens, Greece)
|May 16, 2015
Summary
Maspin expression differs between colorectal lesion types. Widespread cytoplasmic maspin expression was found in serrated lesions (hyperplastic polyps and sessile serrated adenoma/polyps), but not in conventional adenomas, aiding in discrimination.
Area of Science:
- Oncology
- Gastroenterology
- Molecular Biology
Background:
- Maspin is a tumor suppressor protein inhibiting cancer progression.
- Mutant maspin is linked to reduced apoptosis and malignant progression.
- Maspin expression was recently observed in serrated colonic lesions.
Purpose of the Study:
- To investigate maspin expression patterns in various colorectal lesions.
- To determine if maspin expression can differentiate serrated lesions from conventional adenomas.
Main Methods:
- Maspin expression was analyzed in hyperplastic polyps (HP), sessile serrated adenoma/polyps (SSA/P), and conventional colorectal adenomas (CCRA).
- Immunohistochemical analysis was performed on 10 colorectal lesions.
Main Results:
- Widespread cytoplasmic maspin expression was detected in all HP and SSA/P samples.
- Focal maspin expression was observed in CCRA samples.
- Normal colonic mucosa adjacent to lesions showed no maspin expression.
Conclusions:
- Maspin expression patterns may help distinguish serrated colonic lesions from conventional adenomas.
- These preliminary findings suggest maspin as a potential diagnostic marker.
